The greatest improvements were seen in the triplet therapy arm, which combined semaglutide, trevogrumab, and garetosmab
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Side effects from semaglutide (nausea, constipation, mild headache) are mediated through GLP-1 pathways and are not exacerbated by concurrent HRT
Both medications target overlapping metabolic pathwayssemaglutide activates GLP-1 receptors, while tirzepatide activates both GLP-1 and GIP receptorsraising questions about additive effects, tolerability, and actual clinical benefit
Ozempic is FDA-approved for diabetes, Wegovy is FDA-approved for weight loss, and Rybelsus is an oral tablet FDA-approved for type 2 diabetes